产品
编 号：F397266
分子式：C26H43NO3
分子量：417.62
分子式：C26H43NO3
分子量：417.62
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 58493-49-5
产品详情
生物活性：
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.
体内研究：
Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor.?Olvanil may have causes an anxiogenic-like effect.?Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0.Animal Model:Sprague-Dawley rats weighing approximately 200 g
Dosage:0, 0.2, 1.0 and 5.0 mg/kg
Administration:Injected intraperitoneally 30 min before the behavioral tests
Result:The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose. The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.?
体外研究：
Olvanil affects C6 glioma cell proliferation (IC50?value of 5.5 μM)
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.
体内研究：
Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor.?Olvanil may have causes an anxiogenic-like effect.?Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0.Animal Model:Sprague-Dawley rats weighing approximately 200 g
Dosage:0, 0.2, 1.0 and 5.0 mg/kg
Administration:Injected intraperitoneally 30 min before the behavioral tests
Result:The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose. The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.?
体外研究：
Olvanil affects C6 glioma cell proliferation (IC50?value of 5.5 μM)
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