产品
编 号：F397175
分子式：C19H27NO3
分子量：317.43
分子式：C19H27NO3
分子量：317.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
400
In-stock
100mg
600
In-stock
200mg
960
In-stock
500mg
1960
In-stock
结构图
CAS No: 58-46-8
产品详情
生物活性：
Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.
体内研究：
Tetrabenazine (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice.Tetrabenazine (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice.Tetrabenazine (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat.Animal Model:Adult male MAO A KO or wide type mice aged 1-2 months
Dosage:1-10 mg/kg
Administration:Subcutaneous injection; once
Result:Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.
Animal Model:Male ICR mice (10 weeks old)
Dosage:0-2 mg/kg
Administration:Intraperitoneal injection; once
Result:Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.
Animal Model:Adult male Sprague-Dawley rat weighed 350-450 g
Dosage:0.25-2 mg/kg
Administration:Intraperitoneal injection; once a week
Result:Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.
Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.
体内研究：
Tetrabenazine (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice.Tetrabenazine (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice.Tetrabenazine (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat.Animal Model:Adult male MAO A KO or wide type mice aged 1-2 months
Dosage:1-10 mg/kg
Administration:Subcutaneous injection; once
Result:Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.
Animal Model:Male ICR mice (10 weeks old)
Dosage:0-2 mg/kg
Administration:Intraperitoneal injection; once
Result:Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.
Animal Model:Adult male Sprague-Dawley rat weighed 350-450 g
Dosage:0.25-2 mg/kg
Administration:Intraperitoneal injection; once a week
Result:Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.
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