产品
编 号：F396817
分子式：C24H40N8O4
分子量：504.63
分子式：C24H40N8O4
分子量：504.63
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
325
In-stock
结构图
CAS No: 58-32-2
产品详情
生物活性：
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.
体内研究：
Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues.Animal Model:C57BL/6-LLC tumor-bearing mice models
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once daily for 18 days
Result:Mitigated tumor growth in tumor-bearing mice.
体外研究：
Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.?Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.?Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation.
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.
体内研究：
Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues.Animal Model:C57BL/6-LLC tumor-bearing mice models
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once daily for 18 days
Result:Mitigated tumor growth in tumor-bearing mice.
体外研究：
Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.?Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.?Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation.
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