产品
编 号：F396716
分子式：C11H8O2
分子量：172.18
分子式：C11H8O2
分子量：172.18
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
520
In-stock
结构图
CAS No: 58-27-5
产品详情
生物活性：
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer.
体内研究：
Menadione (25-150 mg/kg, 静脉注射, 一次或每隔一天共五次) 在雄性 Wister 大鼠中单次注射比五次注射产生更严重的损伤。Animal Model:Male Wister rats
Dosage:25-150 mg/kg
Administration:i.v., once time or every other day for five times
Result:Showed microgranular degeneration of renal tubular cells at the dose of 25 mg/kg.Observed microgranular degeneration of renal tubular cells and mild pulmonary hemorrhage at the dose of 50 mg/kg.Produced lesions in the kidney, heart, liver and lung at the dose of 100-150 mg/kg.Showed kidney apoptosis at the dose of 100-150 mg/kg.
体外研究：
Menadione (0-100 μM, 24-72 h) 可在高浓度 (100 μM) 下诱导 AR4-2J 细胞坏死，在低浓度 (10-20 μM) 下诱导细胞凋亡。
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer.
体内研究：
Menadione (25-150 mg/kg, 静脉注射, 一次或每隔一天共五次) 在雄性 Wister 大鼠中单次注射比五次注射产生更严重的损伤。Animal Model:Male Wister rats
Dosage:25-150 mg/kg
Administration:i.v., once time or every other day for five times
Result:Showed microgranular degeneration of renal tubular cells at the dose of 25 mg/kg.Observed microgranular degeneration of renal tubular cells and mild pulmonary hemorrhage at the dose of 50 mg/kg.Produced lesions in the kidney, heart, liver and lung at the dose of 100-150 mg/kg.Showed kidney apoptosis at the dose of 100-150 mg/kg.
体外研究：
Menadione (0-100 μM, 24-72 h) 可在高浓度 (100 μM) 下诱导 AR4-2J 细胞坏死，在低浓度 (10-20 μM) 下诱导细胞凋亡。
产品资料
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