产品
编 号：F396266
分子式：C6H11NaO3
分子量：154.14
分子式：C6H11NaO3
分子量：154.14
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CAS No: 581099-89-0
产品详情
生物活性：
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.
体内研究：
UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats.Animal Model:Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training
Dosage:320, 660, 1000, 1778 mg/kg
Administration:I.p. injection
Result:Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
体外研究：
UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB.UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors.
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds.
体内研究：
UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats.Animal Model:Adult male Sprague-Dawley rats (250-300 g) are carried out discrimination training
Dosage:320, 660, 1000, 1778 mg/kg
Administration:I.p. injection
Result:Caused vehicle-lever responding up to a dose (1778 mg/kg) that decreased markedly or eliminated lever pressing.
体外研究：
UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB.UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors.
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