产品
编 号：F395872
分子式：C25H22F3N7O4S
分子量：573.55
分子式：C25H22F3N7O4S
分子量：573.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
183
In-stock
5mg
400
In-stock
10mg
640
In-stock
25mg
1200
In-stock
50mg
1920
In-stock
100mg
3000
In-stock
结构图
CAS No: 579515-63-2
产品详情
生物活性：
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis.
体外研究：
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner.?GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis.
体外研究：
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner.?GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
产品资料
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