产品
编 号：F395585
分子式：C8H15N3O4
分子量：217.22
分子式：C8H15N3O4
分子量：217.22
产品类型
规格
价格
是否有货
结构图
CAS No: 57836-11-0
产品详情
生物活性：
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation.
体内研究：
H-Gly-Sar-Sar-OH (0.1 mM；灌注；单剂量) 在 Sprague-Dawley 大鼠肾脏中未显著被水解 (给药 60 min) 或清除。H-Gly-Sar-Sar-OH (10 mg/kg；口服；单剂量) 在自发性高血压大鼠 (SHRs) 中显示出稳定性。H-Gly-Sar-Sar-OH 在自发性高血压大鼠中的药代动力学 (PK) 参数Week oldCmax (nmol/mL, plasma)Tmax (min)AUC0-90 min (nmol?min/mL, plasma)T1/2 (min)
84.6±0.630258.0±32.175
4010.7±1.530621.0±86.383
Animal Model:Male Sprague-Dawley rats (350 g).
Dosage:0.1 mM.
Administration:Perfusion (kidney); single dose.
Result:Showed stability.
Animal Model:Male SHRs (8 and 40 week-old).
Dosage:10 mg/kg.
Administration:Oral gavage; single dose.
Result:Detected in full form.
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation.
体内研究：
H-Gly-Sar-Sar-OH (0.1 mM；灌注；单剂量) 在 Sprague-Dawley 大鼠肾脏中未显著被水解 (给药 60 min) 或清除。H-Gly-Sar-Sar-OH (10 mg/kg；口服；单剂量) 在自发性高血压大鼠 (SHRs) 中显示出稳定性。H-Gly-Sar-Sar-OH 在自发性高血压大鼠中的药代动力学 (PK) 参数Week oldCmax (nmol/mL, plasma)Tmax (min)AUC0-90 min (nmol?min/mL, plasma)T1/2 (min)
84.6±0.630258.0±32.175
4010.7±1.530621.0±86.383
Animal Model:Male Sprague-Dawley rats (350 g).
Dosage:0.1 mM.
Administration:Perfusion (kidney); single dose.
Result:Showed stability.
Animal Model:Male SHRs (8 and 40 week-old).
Dosage:10 mg/kg.
Administration:Oral gavage; single dose.
Result:Detected in full form.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备