产品
编 号：F395206
分子式：C4H7NO2
分子量：101.1
分子式：C4H7NO2
分子量：101.1
产品类型
规格
价格
是否有货
100mg
320
In-stock
结构图
CAS No: 57-71-6
产品详情
生物活性：
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release.
体内研究：
Biacetyl monoxime (0-200 mg/kg; i.v.; once) shows hypotensive effect.Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions.Animal Model:Male SHR and age-matched WKY rat
Dosage:5, 30, I00 and 200 mg/kg
Administration:Intravenous administration, 1 mL/kg, once
Result:Decreased arterial blood pressure for both strains, the SHR was significantly more responsive.
Animal Model:Male mice (20 to 25 g)
Dosage:51, 103 and 205 mg/kg in combination with intraperitoneal injection of 3.0 mg/kg Picrotoxin (HY-101391)
Administration:Intraperitoneal injection, once
Result:Showed dose-dependent anticonvulsant effect against Picrotoxin-induced convulsions.
体外研究：
Biacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea.Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum.Biacetyl monoxime (0-30 mM) induces SR Ca2+ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction.Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI.Biacetyl monoxime (0-50 mM) suppresses L-type Ca2+ current of single cardiac myocytes isolated from SHR and WKY rats.Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release.
体内研究：
Biacetyl monoxime (0-200 mg/kg; i.v.; once) shows hypotensive effect.Biacetyl monoxime (0-205 mg/kg; i.p.; once) shows anticonvulsant effect against Picrotoxin (HY-101391)-induced convulsions.Animal Model:Male SHR and age-matched WKY rat
Dosage:5, 30, I00 and 200 mg/kg
Administration:Intravenous administration, 1 mL/kg, once
Result:Decreased arterial blood pressure for both strains, the SHR was significantly more responsive.
Animal Model:Male mice (20 to 25 g)
Dosage:51, 103 and 205 mg/kg in combination with intraperitoneal injection of 3.0 mg/kg Picrotoxin (HY-101391)
Administration:Intraperitoneal injection, once
Result:Showed dose-dependent anticonvulsant effect against Picrotoxin-induced convulsions.
体外研究：
Biacetyl monoxime (Diacetyl monoxime) (50 mM, 6 and 48 h) decreases cellulase secretion in C. cinerea.Biacetyl monoxime (50 mM, 2 and 4 h) disrupts the localization of the Golgi apparatus, but not that of the endoplasmic reticulum.Biacetyl monoxime (0-30 mM) induces SR Ca2+ release (no efflux inhibitors) in a concentration-dependent manner, with a maximal reduction of 72% of SR Ca2+ at pCa 6.0.Biacetyl monoxime acts as a chemical phosphatase, which has led to speculation that dephosphorylation of key Ca2+ channel proteins may be involved in its inhibition of contraction.Biacetyl monoxime does not inhibit the ATPase activity of two different myosin-I isoforms, myosin-V, or myosin-VI.Biacetyl monoxime (0-50 mM) suppresses L-type Ca2+ current of single cardiac myocytes isolated from SHR and WKY rats.Biacetyl monoxime significantly reduces the duration of both spontaneous and electrically stimulated action potentials of cultured neonatal rat cardiomyocytes.
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