产品
编 号：F395008
分子式：C11H11ClN4O2
分子量：266.68
分子式：C11H11ClN4O2
分子量：266.68
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 57653-26-6
产品详情
生物活性：
Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction.
体内研究：
Fenobam (30-60 mg/kg; p.o.; 3 times a week) 显著抑制大鼠的自我给药行为。Animal Model:Male Long-Evans rats (250-300 g).
Dosage:30-60 mg/kg
Administration:Oral administration; 3 times a week.
Result:Inhibited self-administration.
体外研究：
Fenobam (300 μM; 72 h) 显著抑制 LM7 细胞的增殖，并诱导细胞凋亡。
Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction.
体内研究：
Fenobam (30-60 mg/kg; p.o.; 3 times a week) 显著抑制大鼠的自我给药行为。Animal Model:Male Long-Evans rats (250-300 g).
Dosage:30-60 mg/kg
Administration:Oral administration; 3 times a week.
Result:Inhibited self-administration.
体外研究：
Fenobam (300 μM; 72 h) 显著抑制 LM7 细胞的增殖，并诱导细胞凋亡。
产品资料
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