产品
编 号：F394499
分子式：C6H8O4
分子量：144.13
分子式：C6H8O4
分子量：144.13
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 5746-90-7
产品详情
生物活性：
3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research.
体内研究：
Animal Model:Male Sprague-Dawley rats and male Hartley guinea-pigs
Dosage:0.16 mL/kg, 90 min
Administration:Intraperitoneal injection (i.p.)
Result:Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs).
Animal Model:Male Wistar rats
Dosage:45mg/kg for single dose, 4days
Administration:Intraperitoneal injection (i.p.)
Result:Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells.
体外研究：
3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导脂质氧化损伤，抗氧化物 (TRO, MEL and SOD plus CAT) 在5 mM剂量下能防止脂质过氧化。3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导蛋白质氧化损伤并降低非酶抗氧化防御。
3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research.
体内研究：
Animal Model:Male Sprague-Dawley rats and male Hartley guinea-pigs
Dosage:0.16 mL/kg, 90 min
Administration:Intraperitoneal injection (i.p.)
Result:Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs).
Animal Model:Male Wistar rats
Dosage:45mg/kg for single dose, 4days
Administration:Intraperitoneal injection (i.p.)
Result:Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells.
体外研究：
3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导脂质氧化损伤，抗氧化物 (TRO, MEL and SOD plus CAT) 在5 mM剂量下能防止脂质过氧化。3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导蛋白质氧化损伤并降低非酶抗氧化防御。
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