产品
编 号：F393620
分子式：C24H30Cl2N2O3
分子量：465.41
分子式：C24H30Cl2N2O3
分子量：465.41
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CAS No: 57149-08-3
产品详情
生物活性：
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.
体内研究：
Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft
Dosage:10 mg/kg
Administration:Oral administration, daily, for 28 days
Result:Decreased tumor weights.
体外研究：
Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.
体内研究：
Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft
Dosage:10 mg/kg
Administration:Oral administration, daily, for 28 days
Result:Decreased tumor weights.
体外研究：
Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
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