产品
编 号：F393619
分子式：C24H28N2O3
分子量：392.49
分子式：C24H28N2O3
分子量：392.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
512
In-stock
5g
720
In-stock
10g
1200
In-stock
结构图
CAS No: 57149-07-2
产品详情
生物活性：
Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia.
体内研究：
Naftopidil (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.Animal Model:Male athymic mice (7-8 weeks), with E9+PrSC xenograft
Dosage:10 mg/kg
Administration:Oral administration, daily, for 28 days
Result:Decreased tumor weights.
体外研究：
Naftopidil suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia.
体内研究：
Naftopidil (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.Animal Model:Male athymic mice (7-8 weeks), with E9+PrSC xenograft
Dosage:10 mg/kg
Administration:Oral administration, daily, for 28 days
Result:Decreased tumor weights.
体外研究：
Naftopidil suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
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