产品
编 号：F393576
分子式：C46H58ClN5O8
分子量：844.43
分子式：C46H58ClN5O8
分子量：844.43
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CAS No: 57132-53-3
产品详情
生物活性：
Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9?μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research.
体内研究：
Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate.Animal Model:Sprague-Dawley rats (6 weeks)
Dosage:0, 0.3, 3, 9, 30 mg/kg
Administration:Orally, once
Result:Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.
体外研究：
Proglumetacin strongly inhibits 5-HETE formation, with an IC50 of 1.5 μM.Proglumetacin inhibits leukocyte migration by inhibiting the production of the chemotactic cyclo-oxygenase product thromboxane B2.
Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9?μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research.
体内研究：
Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate.Animal Model:Sprague-Dawley rats (6 weeks)
Dosage:0, 0.3, 3, 9, 30 mg/kg
Administration:Orally, once
Result:Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.
体外研究：
Proglumetacin strongly inhibits 5-HETE formation, with an IC50 of 1.5 μM.Proglumetacin inhibits leukocyte migration by inhibiting the production of the chemotactic cyclo-oxygenase product thromboxane B2.
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