产品
编 号：F393389
分子式：C19H42BrN
分子量：364.45
分子式：C19H42BrN
分子量：364.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 57-09-0
产品详情
生物活性：
Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction.
体内研究：
Cetrimonium bromide (5 mg/kg，腹腔注射，一天一次，连续 5 天) 可减弱 FaDu 细胞荷瘤小鼠的成瘤能力，延缓肿瘤生长。Cetrimonium bromide (10-45 mg/kg，饮水中补充，一天一次，连续 1 年) 对大鼠有亚急性和慢性毒性。Animal Model:FaDu cells tumor-bearing mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Induced a modest reduction in tumor development.Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days.
Animal Model:Sprague-Dawley rats
Dosage:10 mg/kg, 20 mg/kg, 45 mg/kg
Administration:Supplemented in drinking water
Result:Showed lower body weight at highest concentration within 3 weeks.Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females.Significantly decreased efficiency of food conversion in male rats receiving the highest dose.
体外研究：
Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells.Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells.Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells.Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells.
Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction.
体内研究：
Cetrimonium bromide (5 mg/kg，腹腔注射，一天一次，连续 5 天) 可减弱 FaDu 细胞荷瘤小鼠的成瘤能力，延缓肿瘤生长。Cetrimonium bromide (10-45 mg/kg，饮水中补充，一天一次，连续 1 年) 对大鼠有亚急性和慢性毒性。Animal Model:FaDu cells tumor-bearing mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Induced a modest reduction in tumor development.Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days.
Animal Model:Sprague-Dawley rats
Dosage:10 mg/kg, 20 mg/kg, 45 mg/kg
Administration:Supplemented in drinking water
Result:Showed lower body weight at highest concentration within 3 weeks.Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females.Significantly decreased efficiency of food conversion in male rats receiving the highest dose.
体外研究：
Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells.Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells.Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells.Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备