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编 号:F393096
分子式:C21H34O4
分子量:350.49
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生物活性:
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation.

体内研究:
U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR).Animal Model:12-15 weeks-old male and female SHR
Dosage:5 μg/kg
Administration:Intravenous injection
Result:Induceed a significant increase of MABP after 1 min in male SHR.

体外研究:
U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively.?U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency.?U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets.?U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways.
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