产品
编 号：F393059
分子式：C17H27N3O7S
分子量：417.48
分子式：C17H27N3O7S
分子量：417.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
425
In-stock
10mg
680
In-stock
100mg
2456
In-stock
结构图
CAS No: 56974-61-9
产品详情
生物活性：
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation.
体内研究：
Gabexate mesylate (FOY；20 mg/kg；腹膜注射；每天；从第 3 天到第 14 天) 可减轻脊神经结扎 (SNL) 引起的机械性异常性疼痛的发展。Gabexate mesylate 对 SNL 后短期内促炎细胞因子的表达具有抑制作用。 Animal Model:Male Sprague-Dawley rats (100-120 g) with spinal nerve ligation (SNL)
Dosage:20 mg/kg
Administration:Intraperitoneally; daily; from 3rd day until the 14th day
Result:Showed a higher PWT than those of the vehicle-treated group. Markedly decreased the expression of p65. Attenuated the expressions of IL-1, IL-6, and TNF-α at 7th day.
体外研究：
Gabexate mesylate (FOY；100-1000 μM；72 小时) 以剂量依赖性方式降低增殖率。
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation.
体内研究：
Gabexate mesylate (FOY；20 mg/kg；腹膜注射；每天；从第 3 天到第 14 天) 可减轻脊神经结扎 (SNL) 引起的机械性异常性疼痛的发展。Gabexate mesylate 对 SNL 后短期内促炎细胞因子的表达具有抑制作用。 Animal Model:Male Sprague-Dawley rats (100-120 g) with spinal nerve ligation (SNL)
Dosage:20 mg/kg
Administration:Intraperitoneally; daily; from 3rd day until the 14th day
Result:Showed a higher PWT than those of the vehicle-treated group. Markedly decreased the expression of p65. Attenuated the expressions of IL-1, IL-6, and TNF-α at 7th day.
体外研究：
Gabexate mesylate (FOY；100-1000 μM；72 小时) 以剂量依赖性方式降低增殖率。
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