产品
编 号：F392871
分子式：C19H11N3Na2O7S2
分子量：503.42
分子式：C19H11N3Na2O7S2
分子量：503.42
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 56932-43-5
产品详情
生物活性：
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).
体内研究：
NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity.Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice.
Dosage:30?mg/kg.
Administration:IP once daily for 15 days.
Result:Significantly inhibited NB tumor growth.
体外研究：
NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines.NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation.
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).
体内研究：
NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity.Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice.
Dosage:30?mg/kg.
Administration:IP once daily for 15 days.
Result:Significantly inhibited NB tumor growth.
体外研究：
NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines.NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation.
产品资料
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