产品
编 号：F044042
分子式：C8H14N3O6P
分子量：279.19
分子式：C8H14N3O6P
分子量：279.19
产品类型
规格
价格
是否有货
5mg
264
In-stock
10mg
360
In-stock
50mg
720
In-stock
100mg
1120
In-stock
结构图
CAS No: 113852-37-2
产品详情
生物活性：
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir also has anti-orthopoxvirus and anti-variola activities.
体内研究：
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice.Animal Model:Female weanling BALB/c mice infected with cowpox virus (CPV)
Dosage:100 mg/kg
Administration:Subcutaneous injection; 3-6 days interval; 21 days
Result:Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
体外研究：
Cidofovir (5-100 μM, 72 hours) has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cell counts in a dose-dependent manner.?Cidofovir (10-1000 μM, 24-120 hours) can reduce cancer cell viability and induces apoptosis.
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir also has anti-orthopoxvirus and anti-variola activities.
体内研究：
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice.Animal Model:Female weanling BALB/c mice infected with cowpox virus (CPV)
Dosage:100 mg/kg
Administration:Subcutaneous injection; 3-6 days interval; 21 days
Result:Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
体外研究：
Cidofovir (5-100 μM, 72 hours) has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cell counts in a dose-dependent manner.?Cidofovir (10-1000 μM, 24-120 hours) can reduce cancer cell viability and induces apoptosis.
产品资料
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