产品
编 号：F391768
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 565451-13-0
产品详情
生物活性：
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research.
体内研究：
Raxibacumab (150 μg/kg or 300 μg/kg，静脉注射，单次给药) 首次暴露于炭疽杆菌致死毒素 (LeTx) 后 6 小时内给药，显著改善大鼠预后。Animal Model:In SD rats after the initiation of a 24-h LeTx infusion
Dosage:150 μg/kg or 300 μg/kg
Administration:At the time of or 3, 6, 9, or 12 h after the initiation of LeTx infusion, the rats were randomized to be treated i.v. in a single dose
Result:Significantly improved in outcome when it was administered up to 6 h (and approached significance when administered up to 12 h) after initial exposure to LeTx. Rats receiving raxibacumab within 6 hours of toxin administration had a better survival rate than those that received raxibacumab at 9 or 12 hours.
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research.
体内研究：
Raxibacumab (150 μg/kg or 300 μg/kg，静脉注射，单次给药) 首次暴露于炭疽杆菌致死毒素 (LeTx) 后 6 小时内给药，显著改善大鼠预后。Animal Model:In SD rats after the initiation of a 24-h LeTx infusion
Dosage:150 μg/kg or 300 μg/kg
Administration:At the time of or 3, 6, 9, or 12 h after the initiation of LeTx infusion, the rats were randomized to be treated i.v. in a single dose
Result:Significantly improved in outcome when it was administered up to 6 h (and approached significance when administered up to 12 h) after initial exposure to LeTx. Rats receiving raxibacumab within 6 hours of toxin administration had a better survival rate than those that received raxibacumab at 9 or 12 hours.
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