产品
编 号：F391680
分子式：C3H8NO5P
分子量：169.07
分子式：C3H8NO5P
分子量：169.07
产品类型
规格
价格
是否有货
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 5652-28-8
产品详情
生物活性：
DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect.
体内研究：
DL-AP3 (4 mg/kg, i.p., 持续 5 周) 联合 SKF81297 (1 mg/kg, i.p.) 减少Fmr1 KO 小鼠多动表型。DL-AP3 (4.0-12.0 mg/animal, i.c.v. infusion, 100 μL) 阻断绵羊内脏痛症状的发展，以及血浆中神经内分泌学变化。Animal Model:Fmr1 KO mice
Dosage:4?mg/kg with SKF81297 (1?mg/kg)
Administration:i.p., for 5?weeks.
Result:Reduced the distance traveled by Fmr1 KO mice (open-field test).Reduced the swim latency on the final day in the Fmr1 KO mice (Morris Water Maze test).
Animal Model:Sheep with visceral pain evoked by colonic distension (CD)
Dosage:4.0-12.0 mg/animal
Administration:i.c.v. infusion, 100 μL
Result:Decreased intensity from appearance of clinical signs of visceral pain caused by CD test.Diminished the increase of plasma cortisol, E, NE and DA concentrations caused by visceral pain provoked by CD episode.
体外研究：
DL-AP3 (10 μM，6 小时) 减轻原代神经元中氧-葡萄糖剥夺 (OGD) 引起的损伤 (细胞活力)。DL-AP3 (10 μM，6 小时) 恢复原代神经元中 OGD 诱导的 p-Akt1 水平降低和细胞色素 C 增加。DL-AP3 (1-100 μM) 抑制大鼠脑磷酸丝氨酸磷酸酶的活性，IC50 为 187 μM，Ki 为 77 μM。DL-AP3 (10 μM, 10min) 联合 SKF81297 (5 μM) 在 Fmr1 KO 小鼠的切片中诱导显著的的长时程增强 (LTP)。
DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect.
体内研究：
DL-AP3 (4 mg/kg, i.p., 持续 5 周) 联合 SKF81297 (1 mg/kg, i.p.) 减少Fmr1 KO 小鼠多动表型。DL-AP3 (4.0-12.0 mg/animal, i.c.v. infusion, 100 μL) 阻断绵羊内脏痛症状的发展，以及血浆中神经内分泌学变化。Animal Model:Fmr1 KO mice
Dosage:4?mg/kg with SKF81297 (1?mg/kg)
Administration:i.p., for 5?weeks.
Result:Reduced the distance traveled by Fmr1 KO mice (open-field test).Reduced the swim latency on the final day in the Fmr1 KO mice (Morris Water Maze test).
Animal Model:Sheep with visceral pain evoked by colonic distension (CD)
Dosage:4.0-12.0 mg/animal
Administration:i.c.v. infusion, 100 μL
Result:Decreased intensity from appearance of clinical signs of visceral pain caused by CD test.Diminished the increase of plasma cortisol, E, NE and DA concentrations caused by visceral pain provoked by CD episode.
体外研究：
DL-AP3 (10 μM，6 小时) 减轻原代神经元中氧-葡萄糖剥夺 (OGD) 引起的损伤 (细胞活力)。DL-AP3 (10 μM，6 小时) 恢复原代神经元中 OGD 诱导的 p-Akt1 水平降低和细胞色素 C 增加。DL-AP3 (1-100 μM) 抑制大鼠脑磷酸丝氨酸磷酸酶的活性，IC50 为 187 μM，Ki 为 77 μM。DL-AP3 (10 μM, 10min) 联合 SKF81297 (5 μM) 在 Fmr1 KO 小鼠的切片中诱导显著的的长时程增强 (LTP)。
产品资料
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