产品
编 号：F391460
分子式：C18H34O3
分子量：298.46
分子式：C18H34O3
分子量：298.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 56472-29-8
产品详情
生物活性：
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.
体内研究：
(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)
Dosage:600 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Markedly and significantly inhibited tumour growth.
体外研究：
(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM.(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.
体内研究：
(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells.Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)
Dosage:600 mg/kg
Administration:Oral administration; daily; for 21 days
Result:Markedly and significantly inhibited tumour growth.
体外研究：
(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM.(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.
产品资料
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