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编 号：F391403
分子式：C22H16O3
分子量：328.36
分子式：C22H16O3
分子量：328.36
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CAS No: 564468-51-5
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生物活性：
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly.
体外研究：
Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner.Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM.Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM.Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway.
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly.
体外研究：
Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner.Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM.Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM.Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway.
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