产品
编 号：F390132
分子式：C12H9N3O5S
分子量：307.28
分子式：C12H9N3O5S
分子量：307.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
112
In-stock
5mg
225
In-stock
10mg
360
In-stock
50mg
1176
In-stock
100mg
1592
In-stock
结构图
CAS No: 55981-09-4
产品详情
生物活性：
Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model.
体内研究：
Nitazoxanide exhibits a wide spectrum of in vivo activity against a broad spectrum of intestinal parasites, such as Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, the apicomplexan Cryptosporidium parvum, and enteric bacteria infecting animals and humans. ?Nitazoxanide (50, 75 or 100 mg/kg/day; administered daily by intragastric for up to 25 days) reduces the mortality of Japanese encephalitis virus (JEV) strain-infected mice and protected mice from a lethal dose challenge of JEV.Animal Model:Three-week old female Chinese Kunming mice (12–14 g body weight) were infected intraperitoneally with JEV
Dosage:50, 75 or 100 mg/kg/day
Administration:Administered intragastrically by gavage
Result:50 mg/kg/day, 75 mg/kg/day and 100 mg/kg/day led to 30%, 70% and 90% mice survival, respectively.
体外研究：
Giardia lamblia, a flagellated protozoan, is the most common causative agent of persistent diarrhea worldwide. ?Nitazoxanide exhibits effect on G. lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM.
Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model.
体内研究：
Nitazoxanide exhibits a wide spectrum of in vivo activity against a broad spectrum of intestinal parasites, such as Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, the apicomplexan Cryptosporidium parvum, and enteric bacteria infecting animals and humans. ?Nitazoxanide (50, 75 or 100 mg/kg/day; administered daily by intragastric for up to 25 days) reduces the mortality of Japanese encephalitis virus (JEV) strain-infected mice and protected mice from a lethal dose challenge of JEV.Animal Model:Three-week old female Chinese Kunming mice (12–14 g body weight) were infected intraperitoneally with JEV
Dosage:50, 75 or 100 mg/kg/day
Administration:Administered intragastrically by gavage
Result:50 mg/kg/day, 75 mg/kg/day and 100 mg/kg/day led to 30%, 70% and 90% mice survival, respectively.
体外研究：
Giardia lamblia, a flagellated protozoan, is the most common causative agent of persistent diarrhea worldwide. ?Nitazoxanide exhibits effect on G. lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM.
产品资料
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