产品
编 号：F389880
分子式：C17H23NO4
分子量：305.37
分子式：C17H23NO4
分子量：305.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 55869-99-3
产品详情
生物活性：
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.
体内研究：
Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%.Animal Model:LPS-Induced Shock Mice
Dosage:50 mg/kg
Administration:I.p.
Result:Markedly decreased the mortality to 20%.
体外研究：
Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.
体内研究：
Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%.Animal Model:LPS-Induced Shock Mice
Dosage:50 mg/kg
Administration:I.p.
Result:Markedly decreased the mortality to 20%.
体外研究：
Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
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