产品
编 号：F389778
分子式：C14H20O2
分子量：220.31
分子式：C14H20O2
分子量：220.31
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CAS No: 55837-18-8
产品详情
生物活性：
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
体内研究：
Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity.Animal Model:Sprague-Dawley rats
Dosage:50 and 250 mg/kg
Administration:Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice
Result:Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
体外研究：
Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose.Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure.Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes.Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis.
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
体内研究：
Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity.Animal Model:Sprague-Dawley rats
Dosage:50 and 250 mg/kg
Administration:Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice
Result:Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.
体外研究：
Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose.Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure.Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes.Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis.
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