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编 号：F389559
分子式：C9H7N7NaO2S
分子量：300.25
分子式：C9H7N7NaO2S
分子量：300.25
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CAS No: 55774-33-9
产品详情
生物活性：
Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.
体内研究：
Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) sodium can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice.Animal Model:Outbred female CD-1 mice, Female ICR mice
Dosage:25-400 mg/kg
Administration:Oral gavage; everyday; 10days
Result:Induced a decrease in erythrocyte-related parameters as well as leukocyte-related parameters in a dose-dependent manner.Induced 52.4%, 35.4%, 17.9%, 16.1% and 15.2% reduction in bone marrow cells at concentrations of 40, 60, 80, 100 and 120 mg/kg, respectively while fms-like tyrosine kinase-3(FLT-3) ligand (FL)-related cytokines were increased.Increased induction of apoptosis.
体外研究：
Azathioprine (0-50 μM, 48 hours) sodium can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes.
Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.
体内研究：
Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) sodium can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice.Animal Model:Outbred female CD-1 mice, Female ICR mice
Dosage:25-400 mg/kg
Administration:Oral gavage; everyday; 10days
Result:Induced a decrease in erythrocyte-related parameters as well as leukocyte-related parameters in a dose-dependent manner.Induced 52.4%, 35.4%, 17.9%, 16.1% and 15.2% reduction in bone marrow cells at concentrations of 40, 60, 80, 100 and 120 mg/kg, respectively while fms-like tyrosine kinase-3(FLT-3) ligand (FL)-related cytokines were increased.Increased induction of apoptosis.
体外研究：
Azathioprine (0-50 μM, 48 hours) sodium can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes.
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