产品
编 号:F389217
分子式:C18H24N4OS2
分子量:376.54
产品类型
结构图
CAS No: 556803-08-8
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产品详情
生物活性:
TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones.
体外研究:
TCN 213 (30 μM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits.