产品
编 号：F389119
分子式：C10H22N4
分子量：198.31
分子式：C10H22N4
分子量：198.31
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CAS No: 55-65-2
产品详情
生物活性：
Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
体内研究：
Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker..Animal Model:Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice.
Dosage:30 mg/kg
Administration:Guanethidine(30 mg/kg, s.c., 1 h, diluted in saline)
Result:Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
体外研究：
Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro..
Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.
体内研究：
Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker..Animal Model:Wild-type (WT) Balb/c,TNFR1(-/-)and IFN-γ-γ(-/-) mice.
Dosage:30 mg/kg
Administration:Guanethidine(30 mg/kg, s.c., 1 h, diluted in saline)
Result:Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1(-/-) mice.
体外研究：
Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro..
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