产品
编 号:F388894
分子式:C22H30Cl2N10
分子量:505.45
产品类型
结构图
CAS No: 55-56-1
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产品详情
生物活性:
Chlorhexidine is an antibacterial used as an antiseptic and for other applications. Chlorhexidine is used to clean the skin after an injury, before surgery, or before an injection. Chlorhexidine is also used to clean the hands before a procedure.
体内研究:
Chlorhexidine gluconate (ip) reduces postoperative intra-abdominal infection in mice at the end of colon surgery.Animal Model:One hundred and eighty male Imprinting Control Region (ICR) mice at 6 to8-wk-old (body weight, 25 ± 3 g) were randomized to six groups.
Dosage:Chlorhexidine gluconate 0.05%, and Chlorhexidine gluconate 0.025%.
Administration:One-time intraperitoneal injection.
Result:A total of 48 mice (26.7%) developed postoperative intra-abdominal abscesses. Mice that had Chlorhexidine gluconate 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with that of group D mice that had saline lavage only (P = 0.0113). Microscopic peritoneal fibrosis occurred significantly more among group E mice that had Chlorhexidine gluconate 0.05% lavage compared with group D mice that had saline lavage only (P = < 0.005).