产品
编 号：F388483
分子式：C15H14Cl2N4O2S2
分子量：417.33
分子式：C15H14Cl2N4O2S2
分子量：417.33
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CAS No: 554403-08-6
产品详情
生物活性：
WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.
体内研究：
WAY-181187 (3-30 mg/kg, s.c.) hydrochloride 的急性给药显着增加细胞外 GABA 浓度，而不改变大鼠额叶皮质中谷氨酸或去甲肾上腺素的水平。 此外，WAY-181187 (30 mg/kg, s.c.) hydrochloride 可适度但显着降低皮质多巴胺和 5-HT 水平。Animal Model:Adult male Sprague-Dawley rats weighing 280-350 g
Dosage:3, 10, or 30 mg/kg
Administration:Acute dministered by s.c.
Result:Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
体外研究：
WAY-181187 (1 and 10 μM) hydrochloride 可增强 ERK1/2 的激活。WAY-181187 hydrochloride 还可提高 Fyn 激酶活性。
WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.
体内研究：
WAY-181187 (3-30 mg/kg, s.c.) hydrochloride 的急性给药显着增加细胞外 GABA 浓度，而不改变大鼠额叶皮质中谷氨酸或去甲肾上腺素的水平。 此外，WAY-181187 (30 mg/kg, s.c.) hydrochloride 可适度但显着降低皮质多巴胺和 5-HT 水平。Animal Model:Adult male Sprague-Dawley rats weighing 280-350 g
Dosage:3, 10, or 30 mg/kg
Administration:Acute dministered by s.c.
Result:Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.
体外研究：
WAY-181187 (1 and 10 μM) hydrochloride 可增强 ERK1/2 的激活。WAY-181187 hydrochloride 还可提高 Fyn 激酶活性。
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