产品
编 号:F388051
分子式:C11H11Cl2N3O
分子量:272.13
产品类型
结构图
CAS No: 55294-15-0
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产品详情
生物活性:
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive effects. Muzolimine can be used for the research of cardiovascular disease.
体内研究:
Muzolimine (0-18 mg/kg; p.o. 7-times per week for 3 months) shows a marked diuresis effect in dogs.Animal Model:3 male and 3 female dogs
Dosage:0, 2, 6, 8 and 18 mg/kg
Administration:Oral gavage; 7 times per week for 3 months
Result:Showed significant diuretic results, and increased the water intake of dogs.
体外研究:
Muzolimine (10 μM-1 mM) dose-dependently inhibits ion transport in Ehrlich cells.