产品
编 号：F388042
分子式：C13H10O
分子量：182.22
分子式：C13H10O
分子量：182.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 55290-63-6
产品详情
生物活性：
Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity.
体内研究：
Atractylodin (40 mg/kg, 腹腔注射, 连续 14 天) 可提高右旋糖酐硫酸钠诱导结肠炎小鼠模型小鼠的存活率。Atractylodin (20, 40, 80 mg/kg, 灌胃) 减轻了高脂肪饮食 (HFD) 诱导的小鼠 NAFLD 和棕榈酸 (PA) 诱导的 HepG2 细胞氧化应激。Animal Model:DSS-Induced Colitis Mouse Model
Dosage:40 mg/kg
Administration:i.p.
Result:Reduced colitis symptoms and increased survival rate.
Animal Model:NAFLD mice model
Dosage:20, 40, 80 mg/kg
Administration:i.g.
Result:Reduced the release of ALT, AST, ROS and MDA.Increased the TG, GSH and SOD.
体外研究：
Atractylodin (50 μM, 48 h) 能显著抑制 HCT116 细胞中肿瘤坏死因子-α-诱导的活化 B 核因子 -κ-轻链增强子磷酸化。Atractylodin (10, 20, 40 μM, 24 h) 通过抑制肝细胞铁下垂来减轻 HFD 诱导的 NAFLD。
Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity.
体内研究：
Atractylodin (40 mg/kg, 腹腔注射, 连续 14 天) 可提高右旋糖酐硫酸钠诱导结肠炎小鼠模型小鼠的存活率。Atractylodin (20, 40, 80 mg/kg, 灌胃) 减轻了高脂肪饮食 (HFD) 诱导的小鼠 NAFLD 和棕榈酸 (PA) 诱导的 HepG2 细胞氧化应激。Animal Model:DSS-Induced Colitis Mouse Model
Dosage:40 mg/kg
Administration:i.p.
Result:Reduced colitis symptoms and increased survival rate.
Animal Model:NAFLD mice model
Dosage:20, 40, 80 mg/kg
Administration:i.g.
Result:Reduced the release of ALT, AST, ROS and MDA.Increased the TG, GSH and SOD.
体外研究：
Atractylodin (50 μM, 48 h) 能显著抑制 HCT116 细胞中肿瘤坏死因子-α-诱导的活化 B 核因子 -κ-轻链增强子磷酸化。Atractylodin (10, 20, 40 μM, 24 h) 通过抑制肝细胞铁下垂来减轻 HFD 诱导的 NAFLD。
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