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编 号：F387987
分子式：C20H30O5
分子量：350.45
分子式：C20H30O5
分子量：350.45
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CAS No: 552830-51-0
产品详情
生物活性：
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.
体内研究：
Resolvin E1 (每只小鼠 1.0 μg；50 μg/kg；腹腔注射；第-8、-1 和 0 天) 保护小鼠免受 TNBS (2，4，6-三硝基苯磺酸) 结肠炎。Animal Model:6- to 8-week-old female BALB/c mice (TNBS colitis model)
Dosage:1.0 μg per mouse; 50 μg/kg
Administration:i.p.; on days -8, -1, and 0 before the induction of colitis
Result:Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
体外研究：
Resolvin E1 (0.1-100 nM) 浓度依赖性抑制 TNF-α 诱导的 NF-κB 激活，在 ChemR23 转染的细胞中的 EC50 为 ~1.0 nM。Resolvin E1 (100 nM) 增加外周血单核细胞和 HEK-ChemR23 细胞中细胞外信号调节激酶 (ERK) 丝裂原活化蛋白 (MAP) 激酶的磷酸化。Resolvin E1 特异性地与中性粒细胞上的 LTB 受体 BLT1 和单核细胞上的 ChemR23 相互作用，以在炎症期间调节白细胞4。Resolvin E1 还刺激局部细胞因子的摄取和清除。
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.
体内研究：
Resolvin E1 (每只小鼠 1.0 μg；50 μg/kg；腹腔注射；第-8、-1 和 0 天) 保护小鼠免受 TNBS (2，4，6-三硝基苯磺酸) 结肠炎。Animal Model:6- to 8-week-old female BALB/c mice (TNBS colitis model)
Dosage:1.0 μg per mouse; 50 μg/kg
Administration:i.p.; on days -8, -1, and 0 before the induction of colitis
Result:Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
体外研究：
Resolvin E1 (0.1-100 nM) 浓度依赖性抑制 TNF-α 诱导的 NF-κB 激活，在 ChemR23 转染的细胞中的 EC50 为 ~1.0 nM。Resolvin E1 (100 nM) 增加外周血单核细胞和 HEK-ChemR23 细胞中细胞外信号调节激酶 (ERK) 丝裂原活化蛋白 (MAP) 激酶的磷酸化。Resolvin E1 特异性地与中性粒细胞上的 LTB 受体 BLT1 和单核细胞上的 ChemR23 相互作用，以在炎症期间调节白细胞4。Resolvin E1 还刺激局部细胞因子的摄取和清除。
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