产品
编 号：F387757
分子式：C7H7NO
分子量：121.14
分子式：C7H7NO
分子量：121.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
280
In-stock
结构图
CAS No: 55-21-0
产品详情
生物活性：
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.
体内研究：
Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions.Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature.Animal Model:C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg)
Dosage:160 mg/kg
Administration:IP, 2 injection by a 4 h interval
Result:Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment.
Animal Model:C57B1/6N mice
Dosage:160 mg/kg
Administration:IP, single dosage
Result:Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.
体内研究：
Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions.Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature.Animal Model:C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg)
Dosage:160 mg/kg
Administration:IP, 2 injection by a 4 h interval
Result:Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment.
Animal Model:C57B1/6N mice
Dosage:160 mg/kg
Administration:IP, single dosage
Result:Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.
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