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编 号:F387403
分子式:C19H23ClN2
分子量:314.85
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生物活性:
Triprolidine hydrochloride is an orally active histamine H1 antagonist. Triprolidine hydrochloride has the function of spinal cord motor and sensory block. Triprolidine hydrochloride can be used for the research of allergic rhinitis.

体内研究:
Triprolidine hydrochloride (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats.Animal Model:Male Sprague-Dawley rat (300-350 g)
Dosage:292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg
Administration:Intrathecal injection
Result:Elicited a dose-dependent spinal block.

体外研究:
Triprolidine hydrochloride (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45.
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