产品
编 号：F386978
分子式：C20H24ClN
分子量：313.86
分子式：C20H24ClN
分子量：313.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
480
In-stock
5g
768
In-stock
结构图
CAS No: 549-18-8
产品详情
生物活性：
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.
体内研究：
Amitriptyline hydrochloride (15 mg/kg，腹腔注射) 可激活 TrkA 和 TrkB 受体，并防止红藻氨酸 (HY-N2309) 诱导的 C57BL/6 小鼠脑部神经元凋亡。Amitriptyline hydrochloride (15-25 mg/kg，腹腔注射，5 天) 可诱导小鼠大脑中 TrkA 和 TrkB 异二聚化。Amitriptyline hydrochloride (15 mg/kg，腹膜内注射) 通过激活小鼠体内的 α2-肾上腺素受体发挥抗伤害作用。Animal Model:Mice
Dosage:15-25 mg/kg
Administration:i.p., 5 days
Result:Induces TrkA tyrosine phosphorylation.InducesTrkA and TrkB receptor heterodimerization in the brain.
体外研究：
Amitriptyline hydrochloride (30 分钟) 可保护海马神经元 (T17 细胞) 免于凋亡 (EC50: 50 nM)。Amitriptyline hydrochloride (0.5 μM，30 分钟) 诱导海马神经元中 TrkA 和 TrkB 受体磷酸化和激活。Amitriptyline hydrochloride (500 nM，5 天) 诱导 PC12 细胞中的神经突生长。
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.
体内研究：
Amitriptyline hydrochloride (15 mg/kg，腹腔注射) 可激活 TrkA 和 TrkB 受体，并防止红藻氨酸 (HY-N2309) 诱导的 C57BL/6 小鼠脑部神经元凋亡。Amitriptyline hydrochloride (15-25 mg/kg，腹腔注射，5 天) 可诱导小鼠大脑中 TrkA 和 TrkB 异二聚化。Amitriptyline hydrochloride (15 mg/kg，腹膜内注射) 通过激活小鼠体内的 α2-肾上腺素受体发挥抗伤害作用。Animal Model:Mice
Dosage:15-25 mg/kg
Administration:i.p., 5 days
Result:Induces TrkA tyrosine phosphorylation.InducesTrkA and TrkB receptor heterodimerization in the brain.
体外研究：
Amitriptyline hydrochloride (30 分钟) 可保护海马神经元 (T17 细胞) 免于凋亡 (EC50: 50 nM)。Amitriptyline hydrochloride (0.5 μM，30 分钟) 诱导海马神经元中 TrkA 和 TrkB 受体磷酸化和激活。Amitriptyline hydrochloride (500 nM，5 天) 诱导 PC12 细胞中的神经突生长。
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