产品
编 号：F386911
分子式：C16H15NO4
分子量：285.29
分子式：C16H15NO4
分子量：285.29
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CAS No: 5489-57-6
产品详情
生物活性：
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity .
体内研究：
Arborinine (40、80 mg/kg；灌胃； 21 天) 在小鼠体内显示出抗肿瘤活性。Animal Model:BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)
Dosage:40, 80 mg/kg
Administration:P.o.; for 21 days
Result:Inhibited the growth of tumors while unchanged the body weights.
体外研究：
Arborinine (0, 5, 15, 30 μM; 48 h) 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达。Arborinine (20 μM) 降低 786O 细胞中 UBE2O 蛋白水平的表达。Arborinine (20 μM) 诱导细胞周期停滞在 S 期并抑制细胞凋亡。
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity .
体内研究：
Arborinine (40、80 mg/kg；灌胃； 21 天) 在小鼠体内显示出抗肿瘤活性。Animal Model:BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)
Dosage:40, 80 mg/kg
Administration:P.o.; for 21 days
Result:Inhibited the growth of tumors while unchanged the body weights.
体外研究：
Arborinine (0, 5, 15, 30 μM; 48 h) 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达。Arborinine (20 μM) 降低 786O 细胞中 UBE2O 蛋白水平的表达。Arborinine (20 μM) 诱导细胞周期停滞在 S 期并抑制细胞凋亡。
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