产品
编 号：F386757
分子式：C22H24Cl2N2O4
分子量：451.34
分子式：C22H24Cl2N2O4
分子量：451.34
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 548470-11-7
产品详情
生物活性：
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.
体内研究：
ISRIB (0.25 mg/kg，腹腔注射，每日) 可恢复朊病毒患病小鼠 eIF2α 磷酸化下游的翻译，对朊病毒患病小鼠具有神经保护作用。
体外研究：
ISRIB (200 nM, 2 h) 阻断 U2OS 细胞 eIF2α 磷酸化诱导的应激颗粒形成。
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.
体内研究：
ISRIB (0.25 mg/kg，腹腔注射，每日) 可恢复朊病毒患病小鼠 eIF2α 磷酸化下游的翻译，对朊病毒患病小鼠具有神经保护作用。
体外研究：
ISRIB (200 nM, 2 h) 阻断 U2OS 细胞 eIF2α 磷酸化诱导的应激颗粒形成。
产品资料
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