产品
编 号：F386701
分子式：C16H15N3O4
分子量：313.31
分子式：C16H15N3O4
分子量：313.31
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
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结构图
CAS No: 54824-17-8
产品详情
生物活性：
Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia.
体内研究：
Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice.Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model.Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg.Animal Model:S-180 bearing mice
Dosage:0.5 mg/kg and 1 mg/kg
Administration:Intraperitoneal injection (i.p.) for 1-7 days
Result:Increased in median survival times.
Animal Model:HepG2 xenograft model
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), twice a day.
Result:Exhibited a relative tumor increment rates (T/C) value of 28.8%.
体外研究：
Mitonafide inhibits DNA and RNA synthesis and induces single-strand breaks in the DNA of chinese hamster ovary cells.The incubation of Mitonafide with rat liver microsomes and NADPH under anaerobic conditions results in the formation of a metabolite identified as 5-aminomitonafide.Mitonafide (25, 50 μM, 1 h) induces single-stand breaks in the DNA of L1210 cells.Mitonafide (10-100 μM) exhibits cytotoxic effect in the HOP-62 lung cell line.
Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia.
体内研究：
Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice.Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model.Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg.Animal Model:S-180 bearing mice
Dosage:0.5 mg/kg and 1 mg/kg
Administration:Intraperitoneal injection (i.p.) for 1-7 days
Result:Increased in median survival times.
Animal Model:HepG2 xenograft model
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.), twice a day.
Result:Exhibited a relative tumor increment rates (T/C) value of 28.8%.
体外研究：
Mitonafide inhibits DNA and RNA synthesis and induces single-strand breaks in the DNA of chinese hamster ovary cells.The incubation of Mitonafide with rat liver microsomes and NADPH under anaerobic conditions results in the formation of a metabolite identified as 5-aminomitonafide.Mitonafide (25, 50 μM, 1 h) induces single-stand breaks in the DNA of L1210 cells.Mitonafide (10-100 μM) exhibits cytotoxic effect in the HOP-62 lung cell line.
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