产品
编 号：F386695
分子式：C32H22O10
分子量：566.51
分子式：C32H22O10
分子量：566.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 548-19-6
产品详情
生物活性：
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.
体内研究：
Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects.Animal Model:Adult male Kunming mice (age 8–10weeks, 30–50 g)
Dosage:4 mg/kg
Administration:Daily for 14 days by intraperitoneally (i.p.) prior to LPS (0.83mg/kg) administration.
Result:Markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and reactive oxygen species.
体外研究：
Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner.Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification.Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates.Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling.Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines.
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.
体内研究：
Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects.Animal Model:Adult male Kunming mice (age 8–10weeks, 30–50 g)
Dosage:4 mg/kg
Administration:Daily for 14 days by intraperitoneally (i.p.) prior to LPS (0.83mg/kg) administration.
Result:Markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and reactive oxygen species.
体外研究：
Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner.Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification.Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates.Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling.Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines.
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