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编 号:F386669
分子式:C30H16O8
分子量:504.44
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis.

体内研究:
Hypericin (静脉注射;10 mg/kg;一次) 处理延缓肿瘤生长。Animal Model:18-20 week-old female BALB/c mice injected withCT26 carcinomas
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; once
Result:Showed a four times delayed tumor growth compared to the control groups.

体外研究:
Hypericin (0.25-4 μM;24 h) 抑制成纤维细胞 (Fb)、黑色素细胞 (Mc) 和角质形成细胞 (Kc) 的生长。 Hypericin (3 μM;24 h) 处理可诱导细胞凋亡。
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