产品
编 号：F386603
分子式：C24H40O5
分子量：408.57
分子式：C24H40O5
分子量：408.57
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 547-75-1
产品详情
生物活性：
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .
体内研究：
Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs.Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models.Animal Model:BA depletion pigs
Dosage:20 mg/kg
Administration:Oral administration (p.o.)
Result:Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.
Animal Model:db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model
Dosage:100 mg/kg/day
Administration:Oral administration (p.o.)
Result:Improved oral glucose tolerances shown by lower glucose levels.Increased circulating active GLP-1 levels and fasting insulin levels.
体外研究：
HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells.HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells.
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .
体内研究：
Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs.Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models.Animal Model:BA depletion pigs
Dosage:20 mg/kg
Administration:Oral administration (p.o.)
Result:Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.
Animal Model:db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model
Dosage:100 mg/kg/day
Administration:Oral administration (p.o.)
Result:Improved oral glucose tolerances shown by lower glucose levels.Increased circulating active GLP-1 levels and fasting insulin levels.
体外研究：
HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells.HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells.
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