产品
编 号：F386405
分子式：C20H28O4
分子量：332.43
分子式：C20H28O4
分子量：332.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 54706-99-9
产品详情
生物活性：
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).
体内研究：
20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice.Animal Model:10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM)
Dosage:20 mg/kg
Administration:I.p. one time per day, for eight consecutive weeks
Result:Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group.Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery.Had less erosion on the surface of the articular cartilage and more proteoglycan content.Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a.Increased the nuclear level of TFEB.
体外研究：
20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100?μM)-induced cell death.20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes.20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10?mM.20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes.20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes.
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).
体内研究：
20-Deoxyingenol (20 mg/kg/d; i.p. for 8 weeks) alleviates the progression of OA in the DMM model in mice.Animal Model:10-week-old C57BL/6 male wild-type (WT) mice with destabilization of the medial meniscus (DMM)
Dosage:20 mg/kg
Administration:I.p. one time per day, for eight consecutive weeks
Result:Had a slightly wider joint space and reduced bone density and calcification compared with the DMM group.Inhibited the decrease in the thickness of hyaline cartilage (HC), and alleviated the disorder and hypertrophy of chondrocytes in the joint tissues of mice after DMM surgery.Had less erosion on the surface of the articular cartilage and more proteoglycan content.Had more positive staining points of LAMP1 and LC3 II, and less cleaved-caspase3 and P16INK4a.Increased the nuclear level of TFEB.
体外研究：
20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100?μM)-induced cell death.20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes.20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10?mM.20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes.20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes.
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