产品
编 号：F386280
分子式：C10H12O3
分子量：180.2
分子式：C10H12O3
分子量：180.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 5466-89-7
产品详情
生物活性：
U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease.
体内研究：
U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg.Animal Model:Male Sprague-Dawley rats (180-250 g)
Dosage:0-250 mg/kg
Administration:i.p.; 10 min
Result:Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg.
体外研究：
U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M.
U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease.
体内研究：
U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg.Animal Model:Male Sprague-Dawley rats (180-250 g)
Dosage:0-250 mg/kg
Administration:i.p.; 10 min
Result:Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg.
体外研究：
U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M.
产品资料
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