产品
编 号：F385895
分子式：C23H30ClNO3
分子量：403.94
分子式：C23H30ClNO3
分子量：403.94
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
结构图
CAS No: 54556-98-8
产品详情
生物活性：
Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
体内研究：
Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.Animal Model:Female adult Sprague-Dawley rats (250-270 g)
Dosage:5 mg dissolved in distilled water (0.5 mL)
Administration:P.o. once daily for 2 weeks
Result:Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.Increased plasma epinephrine and norepinephrine levels.No significant changes were observed in body weight.
体外研究：
Propiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.
Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
体内研究：
Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.Animal Model:Female adult Sprague-Dawley rats (250-270 g)
Dosage:5 mg dissolved in distilled water (0.5 mL)
Administration:P.o. once daily for 2 weeks
Result:Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.Increased plasma epinephrine and norepinephrine levels.No significant changes were observed in body weight.
体外研究：
Propiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.
产品资料
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