产品
编 号：F385765
分子式：C21H21ClN4O3
分子量：412.87
分子式：C21H21ClN4O3
分子量：412.87
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CAS No: 54533-85-6
产品详情
生物活性：
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke.
体内研究：
Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments.Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats.Animal Model:Mice with chronic restraint stress
Dosage:3, 9 mg/kg
Administration:Intraperitoneal injection (i.p.), daily
Result:Increased crossing frequencies of the open field test. Increased in the activities of enzymatic SOD and CAT.
体外研究：
Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers.Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node.Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle.Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension).
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke.
体内研究：
Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments.Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats.Animal Model:Mice with chronic restraint stress
Dosage:3, 9 mg/kg
Administration:Intraperitoneal injection (i.p.), daily
Result:Increased crossing frequencies of the open field test. Increased in the activities of enzymatic SOD and CAT.
体外研究：
Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers.Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node.Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle.Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension).
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