产品
编 号:F385435
分子式:C18H37NO2
分子量:299.49
产品类型
结构图
CAS No: 544-31-0
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产品详情
生物活性:
Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.
体外研究:
Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of Palmitoylethanolamide, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. Palmitoylethanolamide is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which Palmitoylethanolamide decreased the toxicity of virus in the organism is discussed.