产品
编 号：F385416
分子式：C9H11IN2O5
分子量：354.1
分子式：C9H11IN2O5
分子量：354.1
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
168
In-stock
1g
264
In-stock
5g
600
In-stock
结构图
CAS No: 54-42-2
产品详情
生物活性：
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM. Idoxuridine shows anti-orthopoxvirus activity.
体内研究：
Idoxuridine (腹腔注射，50 -200 mg/kg，3 次，间隔 3 小时) 可刺激 C3HeB/FeJ 雌性和雄性小鼠和 A/J 雄性小鼠。Animal Model:C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months
Dosage:50-200 mg/kg
Administration:Intraperitoneal injection, 3 times, 3 hours interval
Result:Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
体外研究：
Idoxuridine (2-10 μM，72 小时) 的 IC50 值为 4.3 μM 的抗病毒药物。
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM. Idoxuridine shows anti-orthopoxvirus activity.
体内研究：
Idoxuridine (腹腔注射，50 -200 mg/kg，3 次，间隔 3 小时) 可刺激 C3HeB/FeJ 雌性和雄性小鼠和 A/J 雄性小鼠。Animal Model:C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months
Dosage:50-200 mg/kg
Administration:Intraperitoneal injection, 3 times, 3 hours interval
Result:Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
体外研究：
Idoxuridine (2-10 μM，72 小时) 的 IC50 值为 4.3 μM 的抗病毒药物。
产品资料
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