产品
编 号：F385192
分子式：C21H23N5O2
分子量：377.44
分子式：C21H23N5O2
分子量：377.44
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 543700-68-1
产品详情
生物活性：
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.
体内研究：
BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models.Animal Model:rodent models of RSV infection(cotton rat and mice)
Dosage:1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:oral, single or bid 4 days
Result:Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
体外研究：
BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM.BMS-433771 can inhibit viral F protein-induced membrane fusion.
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.
体内研究：
BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models.Animal Model:rodent models of RSV infection(cotton rat and mice)
Dosage:1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration:oral, single or bid 4 days
Result:Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
体外研究：
BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM.BMS-433771 can inhibit viral F protein-induced membrane fusion.
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