产品
编 号：F385160
分子式：C14H14N2O
分子量：226.27
分子式：C14H14N2O
分子量：226.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
480
In-stock
500mg
1440
In-stock
结构图
CAS No: 54-36-4
产品详情
生物活性：
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression.
体内研究：
Metyrapone (25 或 50 mg/kg；皮下注射，单次剂量) 可降低应激诱导的血浆皮质酮水平升高，在高剂量时显著损害采集性能，并在低剂量时增加张开臂活动。Animal Model:Male Sprague-Dawley rats (n=179; 270-300g)
Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg)
Administration:SC, single dosage
Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
体外研究：
Metyrapone (100 μM；2 小时) 过度激活 HepG2 中的自噬，并延迟严重内质网 (ER) 应激时细胞凋亡的激活。
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression.
体内研究：
Metyrapone (25 或 50 mg/kg；皮下注射，单次剂量) 可降低应激诱导的血浆皮质酮水平升高，在高剂量时显著损害采集性能，并在低剂量时增加张开臂活动。Animal Model:Male Sprague-Dawley rats (n=179; 270-300g)
Dosage:25 or 50 mg/kg (in a volume of 2.0 mL/kg)
Administration:SC, single dosage
Result:Dose-dependently decreased the stress-induced increase in plasma corticosterone levels in the water maze test; the high level dose significantly impaired acquisition performance in the water maze and decreased fear-induced immobility; the lower dose increased open arm activity.
体外研究：
Metyrapone (100 μM；2 小时) 过度激活 HepG2 中的自噬，并延迟严重内质网 (ER) 应激时细胞凋亡的激活。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备